tert-Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

Org Biomol Chem. 2019 Jan 23;17(4):845-850. doi: 10.1039/c8ob03010c.

Abstract

A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.