What Is New in the 2017 World Health Organization Classification and 8th American Joint Committee on Cancer Staging System for Pancreatic Neuroendocrine Neoplasms?

Jooae Choe; Kyung Won Kim; Hyoung Jung Kim; Dong Wook Kim; Kyu Pyo Kim; Seung-Mo Hong; Jin-Sook Ryu; Sree Harsha Tirumani; Katherine Krajewski; Nikhil Ramaiya

doi:10.3348/kjr.2018.0040

What Is New in the 2017 World Health Organization Classification and 8th American Joint Committee on Cancer Staging System for Pancreatic Neuroendocrine Neoplasms?

Korean J Radiol. 2019 Jan;20(1):5-17. doi: 10.3348/kjr.2018.0040. Epub 2018 Dec 27.

Authors

Affiliations

¹ Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
² Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
³ Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
⁴ Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
⁵ Department of Imaging, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁶ Department of Imaging, UH Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.

Abstract

The diagnosis and management of pancreatic neuroendocrine neoplasms (NENs) have evolved significantly in recent years. There are several diagnostic and therapeutic challenges and controversies regarding the management of these lesions. In this review, we focus on the recent significant changes and controversial issues regarding the diagnosis and management of NENs and discuss the role of imaging in the multidisciplinary team approach.

Keywords: Management; Multidisciplinary; NET; Neuroendocrine tumor; Pancreas; Staging.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Antineoplastic Agents / therapeutic use
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Female
Humans
Male
Neoplasm Staging / methods*
Neuroendocrine Tumors / diagnosis*
Neuroendocrine Tumors / diagnostic imaging*
Neuroendocrine Tumors / drug therapy
Neuroendocrine Tumors / pathology
Pancreas / diagnostic imaging
Pancreas / pathology
Pancreatic Neoplasms / diagnosis*
Pancreatic Neoplasms / diagnostic imaging*
Pancreatic Neoplasms / drug therapy
Pancreatic Neoplasms / pathology
Positron Emission Tomography Computed Tomography
Tomography, X-Ray Computed
United States
World Health Organization

Substances

Antineoplastic Agents