1-Deoxysphingolipids

M A Lone; T Santos; I Alecu; L C Silva; T Hornemann

doi:10.1016/j.bbalip.2018.12.013

1-Deoxysphingolipids

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):512-521. doi: 10.1016/j.bbalip.2018.12.013. Epub 2019 Jan 6.

Authors

M A Lone¹, T Santos², I Alecu³, L C Silva⁴, T Hornemann⁵

Affiliations

¹ Institute for Clinical Chemistry, University Hospital Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland.
² Institute for Clinical Chemistry, University Hospital Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland; iMed.ULisboa - Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal; Centro de Química-Física Molecular and IN-Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
³ Neural Regeneration Laboratory, India Taylor Lipidomic Research Platform, Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Ottawa Brain and Mind Research Institute, University of Ottawa, Canada.
⁴ iMed.ULisboa - Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal; Centro de Química-Física Molecular and IN-Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
⁵ Institute for Clinical Chemistry, University Hospital Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland. Electronic address: thorsten.hornemann@usz.ch.

PMID: 30625374
DOI: 10.1016/j.bbalip.2018.12.013

Abstract

Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and are not degraded over the canonical catabolic pathways. Pathologically elevated 1-deoxySLs are involved in several disease conditions. Within this review, we will provide an up-to-date overview on the metabolic, physiological and pathophysiological aspects of this enigmatic class of "headless" sphingolipids.

Keywords: Alanine; Atypical sphingolipids; Glycine; HSAN1; Serine; Sphingolipid metabolism; T2DM.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Eukaryota / metabolism
Gene Regulatory Networks
Humans
Molecular Structure
Sphingolipids / chemistry*
Sphingolipids / metabolism*

Substances

1-deoxysphingolipid
Sphingolipids