TP53LNC-DB, the database of lncRNAs in the p53 signalling network

Muhammad Riaz Khan; Ihtisham Bukhari; Ranjha Khan; Hafiz Muhammad Jafar Hussain; Mian Wu; Rick Francis Thorne; Jinming Li; Guangzhi Liu

doi:10.1093/database/bay136

TP53LNC-DB, the database of lncRNAs in the p53 signalling network

Database (Oxford). 2019 Jan 1:2019:bay136. doi: 10.1093/database/bay136.

Authors

Muhammad Riaz Khan¹, Ihtisham Bukhari¹, Ranjha Khan², Hafiz Muhammad Jafar Hussain², Mian Wu¹, Rick Francis Thorne¹, Jinming Li¹, Guangzhi Liu¹

Affiliations

¹ Translational Research Institute, Henan Provincial People's Hospital, School of Medicine, Zhengzhou University, Zhengzhou, China.
² Joint Centre for Human Reproduction and Genetics. Anhui Society for Cell Biology. School of Life Sciences, University of Science and Technology of China, Hefei, China.

Abstract

The TP53 gene product, p53, is a pleiotropic transcription factor induced by stress, which functions to promote cell cycle arrest, apoptosis and senescence. Genome-wide profiling has revealed an extensive system of long noncoding RNAs (lncRNAs) that is integral to the p53 signalling network. As a research tool, we implemented a public access database called TP53LNC-DB that annotates currently available information relating lncRNAs to p53 signalling in humans.

Publication types

Dataset
Research Support, Non-U.S. Gov't

MeSH terms

Databases, Genetic*
Genomics
Humans
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
Signal Transduction / genetics*
Tumor Suppressor Protein p53* / genetics
Tumor Suppressor Protein p53* / metabolism

Substances

RNA, Long Noncoding
Tumor Suppressor Protein p53