Kanamycin detection at graphene quantum dot-decorated gold nanoparticles in organized medium after solid-phase extraction using an aminoglycoside imprinted polymer

Carlos A T Toloza; Joseany M S Almeida; Sarzamin Khan; Yasmin G Dos Santos; Andrea R da Silva; Ricardo Q Aucélio

doi:10.1016/j.mex.2018.11.019

Kanamycin detection at graphene quantum dot-decorated gold nanoparticles in organized medium after solid-phase extraction using an aminoglycoside imprinted polymer

MethodsX. 2018 Nov 30:5:1605-1612. doi: 10.1016/j.mex.2018.11.019. eCollection 2018.

Authors

Carlos A T Toloza^{1

2}, Joseany M S Almeida¹, Sarzamin Khan³, Yasmin G Dos Santos¹, Andrea R da Silva⁴, Ricardo Q Aucélio¹

Affiliations

¹ Department of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, 22451-900, Brazil.
² Chemistry Program, Universidad del Atlantico, Puerto Colombia, Colombia.
³ Department of Chemistry, University of Swabi, Khyber Pakhtunkhwa, Anbar, 23561, Pakistan.
⁴ Centro Federal de Educação Tecnológica Celso Suckow da Fonseca (CEFET/RJ), 27600-000, Valença, RJ, Brazil.

Abstract

This is a description of the indirect determination of kanamycin sulfate though the photoluminescence enhancement of an aqueous dispersion of amino-functionalized graphene quantum dots (amino-GQDs) coupled with gold nanoparticles (AuNPs) in a cationic surfactant-rich medium. Specifically, cetyltrimethylammonium bromide (CTAB) was used as the cationic surfactant in our work. Previously, solid phase extraction with a cartridge packed with aminoglycoside-selective imprinted polymer ensured selectivity in kanamycin determination in yellow-fever vaccine and veterinary pharmaceutical samples. The proposed method has trace analysis capability and it is simple to perform as it does not involve the use of toxic reagents employed for chemical derivatization of aminoglycoside antibiotics.

Keywords: Amino-functionalized graphene quantum dots; Gold nanoparticles; Imprinted polymer; Kanamycin sulfate; Nanoparticle based analytical probing; Photoluminescence spectrometry; Photoluminescent nanoprobe; Solid-phase extraction.