Wireless Electrochemical Detection on a Microfluidic Compact Disc (CD) and Evaluation of Redox-Amplification during Flow

Maria Bauer; Jaume Bartoli; Sergio O Martinez-Chapa; Marc Madou

doi:10.3390/mi10010031

Wireless Electrochemical Detection on a Microfluidic Compact Disc (CD) and Evaluation of Redox-Amplification during Flow

Micromachines (Basel). 2019 Jan 7;10(1):31. doi: 10.3390/mi10010031.

Authors

Maria Bauer¹, Jaume Bartoli², Sergio O Martinez-Chapa³, Marc Madou⁴

Affiliations

¹ Department of Mechanical and Aerospace Engineering, University of California Irvine, Irvine, CA 92697, USA. mebauer@uci.edu.
² Department of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA. jbartoli@uci.edu.
³ School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey 64849, NL, Mexico. smart@tec.mx.
⁴ Department of Mechanical and Aerospace Engineering, University of California Irvine, Irvine, CA 92697, USA. mmadou@uci.edu.

Abstract

Novel biomarkers and lower limits of detection enable improved diagnostics. In this paper we analyze the influence of flow on the lower limit of electrochemical detection on a microfluidic Compact Disc (CD). Implementing wireless transfer of data reduces noise during measurements and allows for real time sensing, demonstrated with the ferri-ferroyanide redox-couple in single and dual mode cyclic voltammetry. The impact of flow on redox-amplification and electrode integration for the lowest limit of detection are discussed.

Keywords: CD microfluidics; bioassay platform; collection efficiency; limit of detection; noise mitigation; redox-amplification; wireless sensing.