Could JAG1 protein inhibition prevent colorectal cancer?

Future Oncol. 2019 Feb;15(4):345-347. doi: 10.2217/fon-2018-0760. Epub 2019 Jan 8.

Authors

Erika López-Arribillaga¹, Verónica Rodilla², Lluís Espinosa³

Affiliations

¹ Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science & Technology (BIST), Barcelona, Spain.
² Preclinical Research Program, Vall d'Hebron Institute of Oncology, CIBERONC, Barcelona, Spain.
³ Cancer Research Program, Institut Mar d'Investigacions Mèdiques, CIBERONC, Hospital del Mar, Doctor Aiguader 88, Barcelona 08003, Spain.

PMID: 30620224
DOI: 10.2217/fon-2018-0760

No abstract available

Keywords: Jag1; Notch; colorectal cancer; personalized medicine; therapeutic antibodies.

Publication types

Editorial

MeSH terms

Antineoplastic Agents, Immunological / pharmacology
Antineoplastic Agents, Immunological / therapeutic use
Colorectal Neoplasms / drug therapy
Colorectal Neoplasms / metabolism*
Colorectal Neoplasms / prevention & control*
Humans
Jagged-1 Protein / antagonists & inhibitors*
Molecular Targeted Therapy / methods
Receptors, Notch / metabolism
Signal Transduction / drug effects

Substances

Antineoplastic Agents, Immunological
JAG1 protein, human
Jagged-1 Protein
Receptors, Notch