Tremor Associated with Chronic Inflammatory Demyelinating Polyneuropathy and Anti-Neurofascin-155 Antibodies

Laurent Bailly; Marie Mongin; Cecile Delorme; Emmanuelle Apartis; Samir Saheb; Karine Viala; Emmanuel Roze

doi:10.7916/D81560ZW

Tremor Associated with Chronic Inflammatory Demyelinating Polyneuropathy and Anti-Neurofascin-155 Antibodies

Tremor Other Hyperkinet Mov (N Y). 2018 Dec 4:8:606. doi: 10.7916/D81560ZW. eCollection 2018.

Authors

Laurent Bailly¹, Marie Mongin^{1

2}, Cecile Delorme^{1

2}, Emmanuelle Apartis^{2

3}, Samir Saheb⁴, Karine Viala^{1

5}, Emmanuel Roze^{1

2}

Affiliations

¹ Department of Neurology, AP-HP, Pitié-Salpêtrière Hospital, Paris, FR.
² Faculty of Medicine of Sorbonne University, UMRS 1127 and Inserm U 1127, CNRS UMR 7225, ICM, F-75013, Paris, FR.
³ Department of Neurophysiology, AP-HP, Saint-Antoine Hospital, Paris, FR.
⁴ Department of Hemo-biotherapies, AP-HP, Pitié Salpêtrière Hospital, University of Paris VI, Paris, FR.
⁵ Department of Neurophysiology, AP-HP, Pitié-Salpêtrière Hospital, Paris, FR.

Abstract

Background: Tremor is an underrecognized feature in certain neuropathy subtypes.

Phenomenology shown: We show a patient with a disabling neuropathic tremor and mild cerebellar syndrome associated with chronic inflammatory demyelinating polyneuropathy (CIDP) and anti-neurofascin-155 (NF155) antibodies.

Educational value: Anti-NF155 testing should be considered in patients with CIDP and disabling tremor because of therapeutic implications.

Keywords: Neuropathic tremor; chronic inflammatory demyelinating polyneuropathy; neurofascin‐155.

Publication types

Case Reports

MeSH terms

Autoantibodies / blood*
Cell Adhesion Molecules / blood*
Female
Humans
Middle Aged
Nerve Growth Factors / blood*
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / blood*
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / complications
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis*
Tremor / blood*
Tremor / complications
Tremor / diagnosis*

Substances

Autoantibodies
Cell Adhesion Molecules
NFASC protein, human
Nerve Growth Factors