SAPHO syndrome with enthesopathy

BMJ Case Rep. 2019 Jan 7;12(1):e225929. doi: 10.1136/bcr-2018-225929.

Abstract

Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was first described as chronic recurrent multifocal osteomyelitis. Because of its rarity, a thorough description of its clinical manifestations is lacking. Herein, we describe the clinical manifestations and imaging features, especially the enthesopathy in bilateral Achilles tendons, of a middle-aged Asian woman with SAPHO syndrome, who improved after diclofenac treatment.

Keywords: musculoskeletal and joint disorders; musculoskeletal syndromes; radiology (diagnostics).

Publication types

  • Case Reports

MeSH terms

  • Achilles Tendon / diagnostic imaging
  • Achilles Tendon / pathology
  • Acquired Hyperostosis Syndrome / diagnostic imaging*
  • Acquired Hyperostosis Syndrome / drug therapy
  • Acquired Hyperostosis Syndrome / pathology*
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Chronic Pain / diagnosis*
  • Chronic Pain / etiology
  • Diagnosis, Differential
  • Diclofenac / administration & dosage
  • Diclofenac / therapeutic use
  • Enthesopathy / diagnostic imaging*
  • Enthesopathy / pathology
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Middle Aged
  • Osteomyelitis / diagnostic imaging
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome
  • Ultrasonography / methods
  • Whole Body Imaging / methods

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Diclofenac