The Dilemma of Chronic Recurrent Multifocal Osteomyelitis

Abstract

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare idiopathic inflammatory disease that affects mainly children and young adults, resulting in significant morbidity especially if not diagnosed early. The clinical signs and symptoms are nonspecific, with a consequential delay in diagnosis. Radiological and histopathological criteria are important for its definition. Two cases of CRMO are reported, highlighting the diagnostic challenge and demonstrating the importance of timely investigations.

Keywords: Bone pain; Children; Chronic recurrent multifocal osteomyelitis; Dolor de huesos; Niños; Osteomielitis; Osteomielitis multifocal recurrente crónica; Osteomyelitis.