Glucose-Regulated TET2 Activity Links Cancer to Diabetes

Hari R Singh; Stefan H Stricker

doi:10.1016/j.trecan.2018.10.008

Glucose-Regulated TET2 Activity Links Cancer to Diabetes

Trends Cancer. 2019 Jan;5(1):5-7. doi: 10.1016/j.trecan.2018.10.008. Epub 2018 Nov 7.

Authors

Hari R Singh¹, Stefan H Stricker²

Affiliations

¹ Physics Department E14, Technical University Munich, 85748 Garching, Germany. Electronic address: h.singh@tum.de.
² MCN Junior Research Group, Munich Center for Neurosciences, Ludwig-Maximilian-Universität, Biomedical Center, Grosshaderner Strasse 9, Planegg-Martinsried 82152, Germany; Epigenetic Engineering, Institute of Stem Cell Research, Helmholtz Zentrum, German Research Center for Environmental Health, Neuherberg D-85764, Germany. Electronic address: Stefan.stricker@helmholtz-muenchen.de.

PMID: 30616756
DOI: 10.1016/j.trecan.2018.10.008

Abstract

Diabetes has long been associated with an increased risk of cancer. While many molecular connections likely exist between the diseases, a recent publication discovered a clear molecular link, demonstrating that a glucose-dependent destabilisation of the DNA demethylase TET2 can promote malignant transformation via an AMPK-dependent phosphoswitch.

Publication types

Letter

MeSH terms

DNA-Binding Proteins / metabolism*
Diabetes Mellitus / etiology*
Diabetes Mellitus / metabolism*
Diabetes Mellitus / therapy
Dioxygenases
Disease Susceptibility*
Energy Metabolism
Glucose / metabolism*
Humans
Neoplasms / etiology*
Neoplasms / metabolism*
Neoplasms / therapy
Proto-Oncogene Proteins / metabolism*

Substances

DNA-Binding Proteins
Proto-Oncogene Proteins
Dioxygenases
TET2 protein, human
Glucose