Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae ST258 isolated from a Japanese patient without a history of foreign travel - a new public health concern in Japan: a case report

BMC Infect Dis. 2019 Jan 7;19(1):20. doi: 10.1186/s12879-018-3649-9.

Abstract

Background: Thus far, studies on Klebsiella pneumoniae carbapenemase (KPC)-producing organisms have only been reported in those with a history of foreign travel, and a specific Japanese KPC-producing isolate has not yet been reported.

Case presentation: We describe a Japanese patient, with no history of travel to foreign countries, admitted due to aspiration pneumonia, and a KPC-producing isolate detected in his sputum. Fortunately, his pneumonia resolved. His close contacts did not have a history of foreign travel, and the isolate was not detected in other patients.

Conclusions: The potential for KPC-producing organisms to become endemic in Japan is currently of great concern.

Keywords: Japanese; K. pneumoniae ST258; Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Humans
  • Japan
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / etiology
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / isolation & purification
  • Klebsiella pneumoniae / metabolism*
  • Male
  • Pneumonia, Bacterial / drug therapy
  • Pneumonia, Bacterial / etiology
  • Pneumonia, Bacterial / microbiology*
  • Public Health
  • Sputum / microbiology
  • Travel
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • Bacterial Proteins
  • beta-Lactamases
  • carbapenemase