Presentation and Outcomes of Pregnancy in Patients With Autoimmune Hepatitis

Clin Gastroenterol Hepatol. 2019 Dec;17(13):2819-2821. doi: 10.1016/j.cgh.2018.12.030. Epub 2019 Jan 4.

Abstract

Autoimmune hepatitis (AIH) frequently affects women of childbearing age in whom the desire to have a family raises the question regarding the potential risks for the fetus and the mother. The information on AIH in pregnant patients is scarce.1 The aims of this study were (1) to identify the risk factors associated with flares in pregnant patients diagnosed with AIH, (2) to determine the course of AIH in patients with pregnancy-related flares, and (3) to describe the outcome of AIH diagnosed in the postpartum period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Spontaneous / epidemiology
  • Adult
  • Alanine Transaminase / blood
  • Aspartate Aminotransferases / blood
  • Azathioprine / therapeutic use
  • Cohort Studies
  • Diabetes, Gestational / epidemiology
  • Drug Therapy, Combination
  • Female
  • Glucocorticoids / therapeutic use*
  • Hepatitis, Autoimmune / blood
  • Hepatitis, Autoimmune / drug therapy*
  • Humans
  • Hypertension, Pregnancy-Induced / epidemiology
  • Immunosuppressive Agents / therapeutic use*
  • Postpartum Period
  • Prednisone / therapeutic use
  • Pregnancy
  • Pregnancy Complications / blood
  • Pregnancy Complications / drug therapy*
  • Pregnancy Outcome
  • Retrospective Studies
  • Symptom Flare Up*

Substances

  • Glucocorticoids
  • Immunosuppressive Agents
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Azathioprine
  • Prednisone