Impact of TBX21, GATA3, and FOXP3 gene polymorphisms on acute cellular rejection after liver transplantation

HLA. 2019 Feb;93(2-3):97-101. doi: 10.1111/tan.13458. Epub 2019 Jan 18.

Abstract

The single nucleotide polymorphisms (SNPs) rs4794067, rs2275806, rs2232365, and rs3761548 map in the genes of TBX21, GATA3, and FOXP3 involved in mediating acute cellular rejection. We investigated whether these SNPs are associated with acute cellular liver transplant rejection. The SNPs were analyzed in recipients with early acute cellular rejection (n = 97), recipients with late acute cellular rejection (n = 49), and recipients without rejection (n = 149). There was no association between acute cellular rejection and SNPs rs4794067, rs2275806, and rs2232365. In contrast, the allele -3279A of FOXP3 SNP rs3761548 exhibited a higher frequency in recipients with late acute cellular rejection as compared with recipients without rejection. This result indicates that the allele -3279A of the SNP rs3761548 may predispose to the development of late acute cellular rejection.

Keywords: FOXP3; GATA3; TBX21; acute cellular liver transplant rejection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biopsy
  • Female
  • Forkhead Transcription Factors / genetics*
  • GATA3 Transcription Factor / genetics*
  • Graft Rejection / etiology*
  • Graft Rejection / genetics*
  • Graft Rejection / pathology
  • Humans
  • Liver Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • T-Box Domain Proteins / genetics*

Substances

  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • GATA3 Transcription Factor
  • GATA3 protein, human
  • T-Box Domain Proteins
  • T-box transcription factor TBX21