A Review on Bioengineering Approaches to Insulin Delivery: A Pharmaceutical and Engineering Perspective

Abstract

Diabetes mellitus (DM) is the most prevalent non-contagious disease, which has affected a large number of people all over the world. Among all treatments known to have a positive influence in the control of DM, insulin therapy is the most common and effective one. Nowadays, various methods of insulin delivery are under investigation, which are able to reach a plausible bioavailability with ignorable side effects instead of insulin injection. This article presents a comprehensive review of the insulin therapy approach with a focus on modified methods in insulin delivery strategies and current advances in engineered insulin delivery systems.

Keywords: biomaterials; controlled release; diabetes mellitus; insulin; non-invasive delivery; smart delivery systems.