Background: This meta-analysis was conducted to analyze the correlations of OX40 ligand (OX40L) variants with atherosclerotic cardio-cerebral vascular diseases (ASCVD).
Methods: Systematic literature research was conducted in PubMed, Medline, and Embase. All statistical analyses were conducted with Review Manager.
Results: Totally eighteen studies were enrolled for analyses. Although no any significant correlations between OX40L variants and ASCVD were detected in overall analyses. Further subgroup analyses by ethnicity revealed that rs1234314 variant was significantly associated with ASCVD in East Asians (dominant model: P = 0.03, odds ratios [OR] = 1.15, 95% confidence interval [CI], 1.01-1.31; allele model: P = 0.04, OR = 1.10, 95%CI, 1.00-1.20). When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11).
Conclusions: Our findings suggested that rs17568, rs1234314, and rs3850641 variants might serve as genetic biomarkers of certain types of CAD.
Keywords: OX40 ligand (OX40L); atherosclerotic cardio-cerebral vascular diseases (ASCVD); coronary artery disease (CAD); genetic variants; ischemic stroke (IS); meta-analysis.
© 2019 Wiley Periodicals, Inc.