Novel Direct Conversion of Microglia to Neurons

Dorit Trudler; Stuart A Lipton

doi:10.1016/j.molmed.2018.12.005

Novel Direct Conversion of Microglia to Neurons

Trends Mol Med. 2019 Feb;25(2):72-74. doi: 10.1016/j.molmed.2018.12.005. Epub 2019 Jan 2.

Authors

Dorit Trudler¹, Stuart A Lipton²

Affiliations

¹ Neuroscience Translational Center and Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
² Neuroscience Translational Center and Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Neurosciences, School of Medicine, University of California-San Diego, La Jolla, CA 92093, USA. Electronic address: slipton@scripps.edu.

Abstract

Direct cell reprogramming, the process by which a somatic cell is converted to another cell type, can potentially circumvent epigenetic changes and proliferative stages resulting from de-differentiation. Recently, Matsuda et al. (Pioneer factor NeuroD1 rearranges transcriptional and epigenetic profiles to execute microglia-neuron conversion; Neuronin in press) demonstrated that expression of transcription factor NeuroD1 can convert mouse microglia to neurons, both in vitro and in vivo.

Keywords: NeuroD1; direct conversion; induced neurons; microglia.

Publication types

Comment

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Differentiation
Cellular Reprogramming
Epigenesis, Genetic
Humans
Mice
Microglia*
Neurons*

Substances

Basic Helix-Loop-Helix Transcription Factors
Neurod1 protein, mouse

Abstract

Publication types

MeSH terms

Substances

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