On-demand CO release for amplification of chemotherapy by MOF functionalized magnetic carbon nanoparticles with NIR irradiation

Jizong Yao; Yao Liu; Jiawen Wang; Qin Jiang; Dejun She; Huishu Guo; Nianrong Sun; Zhiqing Pang; Chunhui Deng; Wuli Yang; Shun Shen

doi:10.1016/j.biomaterials.2018.12.029

On-demand CO release for amplification of chemotherapy by MOF functionalized magnetic carbon nanoparticles with NIR irradiation

Biomaterials. 2019 Mar:195:51-62. doi: 10.1016/j.biomaterials.2018.12.029. Epub 2018 Dec 28.

Authors

Jizong Yao¹, Yao Liu², Jiawen Wang¹, Qin Jiang³, Dejun She⁴, Huishu Guo⁵, Nianrong Sun¹, Zhiqing Pang⁶, Chunhui Deng⁷, Wuli Yang⁸, Shun Shen⁹

Affiliations

¹ Department of Chemistry and Institutes of Biomedical Sciences, Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai, 200433, China.
² The Institute for Translational Nanomedicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Central Laboratory, First Affiliated Hospital, Institute (college) of Integrative Medicine, Dalian Medical University, Dalian, 116021, China.
³ State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
⁴ Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
⁵ Central Laboratory, First Affiliated Hospital, Institute (college) of Integrative Medicine, Dalian Medical University, Dalian, 116021, China.
⁶ School of Pharmacy & Key Laboratory of Smart Drug Delivery, Fudan University, Shanghai, 201203, China.
⁷ Department of Chemistry and Institutes of Biomedical Sciences, Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai, 200433, China. Electronic address: chdeng@fudan.edu.cn.
⁸ State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China. Electronic address: wlyang@fudan.edu.cn.
⁹ The Institute for Translational Nanomedicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. Electronic address: nanocarries@gmail.com.

PMID: 30610993
DOI: 10.1016/j.biomaterials.2018.12.029

Abstract

Carbon monoxide (CO) gas therapy combined with chemotherapy and photothermal therapy (PTT) is a promising treatment mode for malignant tumor. Herein, we firstly reported doxorubicin (DOX) loaded Mn carbonyl modified Fe (Ⅲ)-based nanoMOFs (MIL-100) coated PEGylated magnetic carbon nanoparticles (denoted as MCM@PEG-CO-DOX NPs) as theranostics nanoplatforms for near-infrared (NIR)-responded CO-DOX combination therapy. MIL-100 as a good nanocarrier of DOX with high loading capacity can also chelate the Mn carbonyl after a smart modification. Meanwhile, magnetic carbon core possessed photothermal effect, which can convert the NIR light to heat by an 808 nm laser irradiation, resulting in the on-demand release of CO and DOX. As a result, combining with PTT, MCM@PEG-CO-DOX NPs killed tumor efficiently. Moreover, our synthesized MCM@PEG-CO-DOX NPs were capable of realizing tumor dual-mode imaging including magnetic resonance imaging (MRI) and photoacoustic imaging (PAI).

Keywords: CO gas therapy; Carbon nanoparticles; Dual-mode imaging; MOFs; Synergistic treatment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Doxorubicin / chemistry*
Drug Delivery Systems / methods*
Drug Liberation
Mannose / chemistry
Nanoparticles / chemistry*

Substances

Doxorubicin
Mannose