Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection

ChemMedChem. 2019 Feb 19;14(4):454-461. doi: 10.1002/cmdc.201800718. Epub 2019 Jan 25.

Abstract

A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.

Keywords: 1,2,3,4,5-pentathiepin; FIV; HIV; antiviral agents; nucleocapsid protein; varacin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Binding Sites
  • Capsid Proteins / antagonists & inhibitors
  • Capsid Proteins / metabolism
  • Catalytic Domain
  • Cats
  • Cell Line
  • Crystallography, X-Ray
  • Density Functional Theory
  • Humans
  • Immunodeficiency Virus, Feline / drug effects*
  • Immunodeficiency Virus, Feline / metabolism
  • Lentivirus Infections / drug therapy
  • Lentivirus Infections / pathology
  • Models, Biological*
  • Molecular Conformation
  • Thiepins / chemistry*
  • Thiepins / pharmacology
  • Thiepins / therapeutic use
  • Zinc / chemistry
  • Zinc / metabolism*

Substances

  • Antiviral Agents
  • Capsid Proteins
  • Thiepins
  • Zinc