Abstract
A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
Keywords:
1,2,3,4,5-pentathiepin; FIV; HIV; antiviral agents; nucleocapsid protein; varacin.
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Antiviral Agents / therapeutic use
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Binding Sites
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Capsid Proteins / antagonists & inhibitors
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Capsid Proteins / metabolism
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Catalytic Domain
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Cats
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Cell Line
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Crystallography, X-Ray
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Density Functional Theory
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Humans
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Immunodeficiency Virus, Feline / drug effects*
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Immunodeficiency Virus, Feline / metabolism
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Lentivirus Infections / drug therapy
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Lentivirus Infections / pathology
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Models, Biological*
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Molecular Conformation
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Thiepins / chemistry*
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Thiepins / pharmacology
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Thiepins / therapeutic use
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Zinc / chemistry
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Zinc / metabolism*
Substances
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Antiviral Agents
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Capsid Proteins
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Thiepins
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Zinc