Phage Display: An Overview in Context to Drug Discovery

Selena Mimmi; Domenico Maisano; Ileana Quinto; Enrico Iaccino

doi:10.1016/j.tips.2018.12.005

Phage Display: An Overview in Context to Drug Discovery

Trends Pharmacol Sci. 2019 Feb;40(2):87-91. doi: 10.1016/j.tips.2018.12.005. Epub 2018 Dec 31.

Authors

Selena Mimmi¹, Domenico Maisano¹, Ileana Quinto¹, Enrico Iaccino²

Affiliations

¹ Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, Catanzaro, Italy.
² Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, Catanzaro, Italy. Electronic address: iaccino@unicz.it.

PMID: 30606501
DOI: 10.1016/j.tips.2018.12.005

Abstract

Peptides are emerging as a new reliable class of therapeutics and, thanks to their lower cost of production, they are becoming established as perfect drug aspirants. Here, we briefly review the phage display method and its contribution to the identification of peptides of interest for the therapeutic market.

Keywords: drug discovery; peptides; phage display.

Publication types

Letter
Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Surface Display Techniques / methods*
Drug Discovery / methods*
Humans
Molecular Targeted Therapy
Peptides / pharmacology*
Recombinant Proteins / pharmacology

Substances

Peptides
Recombinant Proteins