Growth hormone therapy in children; research and practice - A review

Paulo Ferrez Collett-Solberg; Alexander A L Jorge; Margaret C S Boguszewski; Bradley S Miller; Catherine Seut Yhoke Choong; Pinchas Cohen; Andrew R Hoffman; Xiaoping Luo; Sally Radovick; Paul Saenger

doi:10.1016/j.ghir.2018.12.004

Growth hormone therapy in children; research and practice - A review

Growth Horm IGF Res. 2019 Feb:44:20-32. doi: 10.1016/j.ghir.2018.12.004. Epub 2018 Dec 26.

Affiliations

¹ Pediatric Endocrinology, Departamento de Medicina Interna, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil. Electronic address: paulosolberg@yahoo.com.
² Faculdade de Medicina, Universidade de São Paulo (FMUSP), the Endocrinology Division/Genetic Endocrinology Unit (LIM 25), Brazil. Electronic address: alexj@usp.br.
³ Departamento de Pediatria, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil. Electronic address: margabogus@uol.com.br.
⁴ Pediatric Endocrinology, University of Minnesota Masonic Children's Hospital, USA. Electronic address: mille685@umn.edu.
⁵ Division of Pediatrics School of Medicine, Perth Childrens Hospital, University of Western Australia, Australia. Electronic address: Catherine.Choong@uwa.edu.au.
⁶ Dean, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. Electronic address: hassy@usc.edu.
⁷ Senior Vice Chair for Academic Affairs, Department of Medicine, Stanford University, USA. Electronic address: glands@stanford.edu.
⁸ Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: xpluo888@sina.com.
⁹ Department of Pediatrics, Senior Associate Dean for Clinical and Translational Research, Robert Wood Johnson Medical School, USA. Electronic address: radovick@rutgers.edu.
¹⁰ New York University Winthrop Hospital, 101 Mineola Boulevard, Mineola, NY 11201, USA. Electronic address: phsaenger@gmail.com.

PMID: 30605792
DOI: 10.1016/j.ghir.2018.12.004

Abstract

Short stature remains the most common reason for referral to a pediatric Endocrinologist and its management remains a challenge. One of the main controversies is the diagnosis of idiopathic short stature and the role of new technologies for genetic investigation of children with inadequate growth. Complexities in management of children with short stature includes selection of who should receive interventions such as recombinant human growth hormone, and how should this agent dose be adjusted during treatment. Should anthropometrical data be the primary determinant or should biochemical and genetic data be used to improve growth response and safety? Furthermore, what is considered a suboptimal response to growth hormone therapy and how should this be managed? Treatment of children with short stature remains a "hot" topic and more data is needed in several areas. These issues are reviewed in this paper.

Keywords: Genetic; Growth; Growth hormone; Short stature.

Publication types

Review

MeSH terms

Biomedical Research*
Growth Disorders / drug therapy*
Human Growth Hormone / therapeutic use*
Humans
Practice Guidelines as Topic / standards*
Practice Patterns, Physicians' / standards*

Substances

Human Growth Hormone