Brain Banking for Research into Neurodegenerative Disorders and Ageing

Neurosci Bull. 2019 Apr;35(2):283-288. doi: 10.1007/s12264-018-0326-3. Epub 2019 Jan 2.

Abstract

Advances in cellular and molecular biology underpin most current therapeutic advances in medicine. Such advances for neurological and neurodegenerative diseases are hindered by the lack of similar specimens. It is becoming increasingly evident that greater access to human brain tissue is necessary to understand both the cellular biology of these diseases and their variation. Research in these areas is vital to the development of viable therapeutic options for these currently untreatable diseases. The development and coordination of human brain specimen collection through brain banks is evolving. This perspective article from the Sydney Brain Bank reviews data concerning the best ways to collect and store material for different research purposes.

Keywords: Brain banking; Brain donation; Human brain tissue processing; Neurodegenerative diseases.

Publication types

  • Review

MeSH terms

  • Aging* / pathology
  • Aging* / physiology
  • Biomedical Research* / methods
  • Brain* / pathology
  • Brain* / physiopathology
  • Humans
  • Neurodegenerative Diseases* / pathology
  • Neurodegenerative Diseases* / physiopathology
  • Neurodegenerative Diseases* / therapy
  • Tissue Banks*
  • Tissue Preservation