A large-scale observational study to investigate the current status of diabetes complications and their prevention in Japan: research outline and baseline data for type 1 diabetes-JDCP study 2

Rimei Nishimura; Kazuo Izumi; Yasuaki Hayashino; Hideki Origasa; Mitsuhiko Noda; Kohjiro Ueki; Naoko Tajima

doi:10.1007/s13340-015-0248-5

A large-scale observational study to investigate the current status of diabetes complications and their prevention in Japan: research outline and baseline data for type 1 diabetes-JDCP study 2

Diabetol Int. 2016 Jan 8;7(1):4-11. doi: 10.1007/s13340-015-0248-5. eCollection 2016 Mar.

Authors

Rimei Nishimura^{1

2}, Kazuo Izumi^{1

3}, Yasuaki Hayashino^{1

4}, Hideki Origasa^{1

5}, Mitsuhiko Noda^{1

6

7}, Kohjiro Ueki^{1

8

9}, Naoko Tajima^{1

10}

Affiliations

¹ Japan Diabetes Society, Tokyo, Japan.
² 2Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo, 105-8461 Japan.
³ Japan Agency for Medical Research and Development, Tokyo, Japan.
⁴ 4Tenri Hospital, Nara, Japan.
⁵ 5Department of Biostatistics and Clinical Epidemiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
⁶ 6National Center for Global Health and Medicine, Tokyo, Japan.
⁷ 7Department of Endocrinology and Diabetes, Saitama Medical University, 38 Moro-hongo, Moroyama, Iruma-gun, Saitama Japan.
⁸ 8Department of Molecular Science on Diabetes, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
⁹ 9Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
¹⁰ 10Jikei University School of Medicine, Tokyo, Japan.

Abstract

The JDCP study is a large-scale, prospective observational study designed to elucidate risk factors for diabetic complications as they become manifest in Japanese type 1 and 2 diabetic patients in the course of their observation and follow-up. Of the 6338 patients enrolled in the study, all patients with type 1 diabetes (n = 394) were examined for baseline clinical characteristics, which were summarized as follows: men, n = 174 (44 %); mean age (men/women), 55.3/56.8 years; duration of diabetes, 11.9/11.1 years; and those with a family history of diabetes, 27.7 %/35.6 %; BMI, 22.4/21.8 kg/m² (P = 0.048); HbA1c, 7.9/7.7 %; those with HbA1c < 7 %, 23.1/26.9 %; SBP, 126.0/124.9 mmHg; and LDL-C, 106.1/107.7 mg/dL. Additionally, the insulin dose per patient was shown to be 33.0 U or 0.58 U/kg body weight with self-monitoring of blood glucose being used in 95.8 % of the patients.

Keywords: Diabetic complications; Glycemic control; JDCP study; Nationwide observational study; Type 1 diabetes.

Publication types

Case Reports