Natural compounds acting at P2 receptors alleviate peripheral neuropathy

Brain Res Bull. 2019 Sep:151:125-131. doi: 10.1016/j.brainresbull.2018.12.017. Epub 2018 Dec 29.

Abstract

Neuropathic pain is generally resistant to currently available treatments, and it is often a consequence of nerve injury due to surgery, diabetes or infection. Myocardial ischemic nociceptive signaling increases the sympathoexcitatory reflex to aggravate myocardial injury. Elucidation of the pathogenetic factors might provide a target for optimal treatment. Abundant evidence in the literature suggests that P2X and P2Y receptors play important roles in signal transmission. Traditional Chinese medicines, such as emodin, puerarin and resveratrol, antagonize nociceptive transmission mediated by purinergic 2 (P2) receptors in primary afferent neurons. This review summarizes recently published data on P2 receptor-mediated neuropathic pain and myocardial ischemia in dorsal root ganglia (DRG), superior cervical ganglia (SCG) and stellate ganglia (SG), with a special focus on the beneficial role of natural compounds.

Keywords: Myocardial ischemia; Neuropathic pain; P2 receptors; Traditional Chinese medicine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Ganglia, Spinal / pathology
  • Humans
  • Medicine, Chinese Traditional / methods
  • Myocardial Ischemia / drug therapy
  • Neuralgia / metabolism
  • Neuralgia / therapy*
  • Neurons / physiology
  • Receptors, Purinergic P2 / drug effects
  • Receptors, Purinergic P2 / metabolism*
  • Receptors, Purinergic P2X / drug effects
  • Receptors, Purinergic P2Y / drug effects
  • Reflex / physiology
  • Signal Transduction / physiology
  • Superior Cervical Ganglion / pathology

Substances

  • Receptors, Purinergic P2
  • Receptors, Purinergic P2X
  • Receptors, Purinergic P2Y