Genomic epidemiological investigation of a Streptococcus suis outbreak in Guangxi, China, 2016

Wenhua Huang; Mingliu Wang; Huaijie Hao; Ruifu Yang; Jijie Xie; Jinhong Su; Mei Lin; Yujun Cui; Yongqiang Jiang

doi:10.1016/j.meegid.2018.12.023

Genomic epidemiological investigation of a Streptococcus suis outbreak in Guangxi, China, 2016

Infect Genet Evol. 2019 Mar:68:249-252. doi: 10.1016/j.meegid.2018.12.023. Epub 2018 Dec 28.

Authors

Wenhua Huang¹, Mingliu Wang², Huaijie Hao³, Ruifu Yang¹, Jijie Xie⁴, Jinhong Su⁵, Mei Lin⁶, Yujun Cui⁷, Yongqiang Jiang⁸

Affiliations

¹ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
² Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, China.
³ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, China.
⁴ Jingxi Center for Diseases Control and Prevention, Jingxi, Guangxi, China.
⁵ Hengxian Center for Diseases Control and Prevention, Hengxian, Guangxi, China.
⁶ Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, China. Electronic address: gxlinmei@126.com.
⁷ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Electronic address: cuiyujun.new@gmail.com.
⁸ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Electronic address: jiangyq@nic.bmi.ac.cn.

PMID: 30597207
DOI: 10.1016/j.meegid.2018.12.023

Abstract

In June 2016, a Streptococcus suis outbreak occurred in Guangxi, China. We determined the genetic characteristics of six clinically isolated strains by serotyping, PCR, and whole-genome sequencing, performing genome epidemiology analysis on these and 961 public available S. suis genomes. We also classified the first sequence type ST665 human case. Sporadic and outbreak cases were distinguished by whole-genome sequencing and phylogenomics. This approach could help to prevent and control S. suis epidemics in Guangxi and the wider region.

Keywords: China; Disease outbreaks; Phylogeny; Streptococcus suis; Whole genome sequencing.

Publication types

Historical Article
Research Support, Non-U.S. Gov't

MeSH terms

China / epidemiology
Disease Outbreaks*
Female
Genome, Bacterial*
Genomics* / methods
Geography, Medical
History, 21st Century
Humans
Male
Molecular Epidemiology
Phylogeny
Public Health Surveillance
Streptococcal Infections / epidemiology*
Streptococcal Infections / history
Streptococcal Infections / microbiology*
Streptococcus suis / classification*
Streptococcus suis / genetics*
Streptococcus suis / isolation & purification