Structure of a transporter domain emerges

J Biol Chem. 2018 Dec 28;293(52):20008-20009. doi: 10.1074/jbc.H118.006869.

Abstract

Magnesium homeostasis relies on transporters like the CNNM family, but little information on these proteins' structure and regulation limits our understanding of their biology and functions in disease. New characterization of a conserved cytoplasmic domain now confirms the presence of a self-liganded architecture that is indispensable for Mg2+ efflux and suggests a possible role for a dimeric assembly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cation Transport Proteins / chemistry*
  • Cation Transport Proteins / metabolism*
  • Crystallography, X-Ray
  • Cyclins / chemistry
  • Cyclins / metabolism
  • Humans
  • Magnesium / metabolism*
  • Models, Molecular
  • Protein Conformation
  • Protein Domains

Substances

  • CNNM2 protein, human
  • CNNM3 protein, human
  • CNNM4 protein, human
  • Cation Transport Proteins
  • Cyclins
  • Magnesium

Associated data

  • PDB/1q5o
  • PDB/5k7l