Humulane-type sesquiterpenoids, widely distributed in plants and microbes, include three types: α-humulene, β-humulene, and γ-humulene. Up to now, 98 humulane-type sesquiterpenoids have been reported, which possessed anti-tumor, anti-inflammatory, antibacterial, and antiviral activities. Herein, this paper describes their chemical constituents and pharmacological activities, hoping to bring benefits for further research and lay a foundation for investigating the structure-activity relationships.
Keywords: chemical constituents; humulane; pharmacological activities; sesquiterpenoid.
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