Ultrasonic energy-assisted preparation of β-cyclodextrin-carbon nanofiber composite: Application for electrochemical sensing of nitrofurantoin

Paramasivam Balasubramanian; Muthaiah Annalakshmi; Shen-Ming Chen; Tamilarasan Sathesh; T S T Balamurugan

doi:10.1016/j.ultsonch.2018.12.014

Ultrasonic energy-assisted preparation of β-cyclodextrin-carbon nanofiber composite: Application for electrochemical sensing of nitrofurantoin

Ultrason Sonochem. 2019 Apr:52:391-400. doi: 10.1016/j.ultsonch.2018.12.014. Epub 2018 Dec 8.

Authors

Paramasivam Balasubramanian¹, Muthaiah Annalakshmi¹, Shen-Ming Chen², Tamilarasan Sathesh³, T S T Balamurugan⁴

Affiliations

¹ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan.
² Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan. Electronic address: smchen78@ms15.hinet.net.
³ Department of Energy and Refrigerating Air-Conditioning Engineering, National Taipei University of Technology, Taipei 106, Taiwan.
⁴ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan; Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, No.1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan.

PMID: 30591361
DOI: 10.1016/j.ultsonch.2018.12.014

Abstract

A simple ultrasonic energy assisted synthesis of β-cyclodextrin (β-CD) supported carbon nanofiber composite (CNF) and its potential application in electrochemical sensing of antibiotic nitrofurantoin (NFT) is reported. The elemental composition and surface morphology of the β-CD/CNF composite was validated through Field emission scanning electron microscopy, energy dispersive X-ray microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis. The uniform enfolding of hydrophilic β-CD over CNF enhance the aqueous dispersion and offer abundant active surface to the β-CD/CNF composite. Further, the electrocatalytic efficacy of the β-CD/CNF composite is utilized to fabricate an electrochemical sensor for the high sensitive quantitative detection of NFT. Under optimized analytical conditions, the sensor displays a broad working range of 0.004-308 µM and calculated detection limit of 1.8 nM, respectively. In addition, the sensor showcased a good selectivity, storage, and working stability, with amiable reproducibility. The point-of-care applicability of the sensor was demonstrated with NFT spiked human blood serum and urine sample with reliable analytical performance. The simple, cost-effective NFT sensor based on β-CD/CNF offered outstanding analytical performance in real-world samples with higher reliability.

Keywords: Antimicrobial drug; Electrochemical detection; Host–guest interaction; Hydrophilic polymers; Sonochemical.

MeSH terms

Carbon / chemistry*
Electrochemistry
Electrodes
Hydrogen-Ion Concentration
Nanofibers / chemistry*
Nitrofurantoin / analysis*
Nitrofurantoin / chemistry
Ultrasonic Waves*
beta-Cyclodextrins / chemistry*

Substances

beta-Cyclodextrins
Carbon
Nitrofurantoin