[Emerging Actions of Pterostilebene on Cancer Research]

Zhongguo Fei Ai Za Zhi. 2018 Dec 20;21(12):931-936. doi: 10.3779/j.issn.1009-3419.2018.12.01.
[Article in Chinese]

Abstract

Pterostilbene (3,5-dimethoxy-4'-hydroxystilbene) is a polyphenolic compound primarily found in blueberries, grapes, and a tree wood, pterocarpus marsupium. Studies demonstrate that pterostilbene inhibits a variety of cancers, such as lung, breast, stomach, colon, etc. The anti-cancer activities are related to the regulation of several hallmarks of cancer. Moreover, pterostilbene exhibits much greater bioavailability and bioactivity than resveratrol which warrants further investigation in the anti-cancer functions and mechanisms. .

【中文题目:紫檀芪抗肿瘤作用机制研究进展】 【中文摘要:紫檀芪(3,5-二甲氧基-4’-羟基二苯乙烯)是一种主要存在于蓝莓、葡萄和花榈木中的多酚类化合物。已有的研究发现紫檀芪具有抗肺癌、乳腺癌、胃癌、结肠癌等多种肿瘤的抗癌作用。其作用机制涉及调控影响多种肿瘤生物学特性。此外,紫檀芪具有比白藜芦醇更高的生物利用度和生物活性,其抗肿瘤作用和机制值得深入探讨和研究。 】 【中文关键词:紫檀芪;肿瘤;凋亡;增殖;侵袭】.

Keywords: Apoptosis; Invasion; Neoplasms; Peterostilbene; Proliferation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Humans
  • Neoplasms / drug therapy*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Stilbenes / chemistry
  • Stilbenes / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Stilbenes
  • pterostilbene

Grants and funding

本文受国家自然科学基金(No.81572699, No.81871866)资助