Abstract
The molecular epidemiology of endemic carbapenem-resistant Klebsiella pneumoniae (CRKP), carbapenem-resistant Pseudomonas aeruginosa (CRPA), and carbapenem-resistant Acinetobacter baumannii (CRAB) in an intensive care unit located in an endemic area with high rates of resistance was investigated. A CRPA strain producing VIM and KPC concurrently was detected for the first time in an endemic area. CRKP strains producing K. pneumoniae carbapenemase predominated and were mainly assigned to the "hyperepidemic Greek clone." Predominant OXA-23-like producing CRAB strains were assigned to multiple pulsotypes.
Keywords:
carbapenemase; intensive care unit; molecular epidemiology.
MeSH terms
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Acinetobacter Infections / epidemiology*
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / classification
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Acinetobacter baumannii / drug effects
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Acinetobacter baumannii / genetics*
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Acinetobacter baumannii / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Carbapenems
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Drug Resistance, Multiple, Bacterial / genetics
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Electrophoresis, Gel, Pulsed-Field
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Endemic Diseases*
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Gene Expression
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Greece / epidemiology
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Humans
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Intensive Care Units
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Klebsiella Infections / epidemiology*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / classification
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification
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Microbial Sensitivity Tests
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Molecular Epidemiology
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Phylogeny
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Pseudomonas Infections / epidemiology*
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / classification
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / genetics*
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Pseudomonas aeruginosa / isolation & purification
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beta-Lactamases / genetics
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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beta-Lactamases
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carbapenemase