Precise In Vivo Inflammation Imaging Using In Situ Responsive Cross-linking of Glutathione-Modified Ultra-Small NIR-II Lanthanide Nanoparticles

Angew Chem Int Ed Engl. 2019 Feb 11;58(7):2050-2054. doi: 10.1002/anie.201812878. Epub 2019 Jan 16.

Abstract

To improve the bioimaging signal-to-noise ratio (SNR), long-term imaging capability, and decrease the potential biotoxicity, an in vivo cross-linking strategy was developed by using sub-10 nm, glutathione-modified, lanthanide nanoprobes. After administration, the nanoprobes cross-link in response to reactive oxygen species (ROS) at the inflamed area and enable the quick imaging of ROS in the second near-infrared (NIR-II) window. These nanoprobes could be rapidly excreted due to their ultra-small size. This strategy may also be applied to other ultra-small contrast agents for the precise bioimaging by in situ lesion cross-linking.

Keywords: NIR-II bioimaging; inflammation; in vivo cross-linking; lanthanide; ultra-small nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cross-Linking Reagents / chemistry*
  • Fluorescent Dyes / chemistry*
  • Glutathione / chemistry*
  • Humans
  • Inflammation / diagnostic imaging*
  • Infrared Rays
  • Lanthanoid Series Elements / chemistry*
  • Metal Nanoparticles / chemistry*
  • Molecular Structure
  • Optical Imaging
  • Particle Size

Substances

  • Cross-Linking Reagents
  • Fluorescent Dyes
  • Lanthanoid Series Elements
  • Glutathione