Chitosan/beidellite nanocomposite as diclofenac carrier

Dorsaf Cheikh; Fátima García-Villén; Hatem Majdoub; César Viseras; Memia Benna Zayani

doi:10.1016/j.ijbiomac.2018.12.205

Chitosan/beidellite nanocomposite as diclofenac carrier

Int J Biol Macromol. 2019 Apr 1:126:44-53. doi: 10.1016/j.ijbiomac.2018.12.205. Epub 2018 Dec 23.

Authors

Dorsaf Cheikh¹, Fátima García-Villén², Hatem Majdoub³, César Viseras⁴, Memia Benna Zayani⁵

Affiliations

¹ Laboratory of Application of Chemistry to Natural Resources, Substances and the Environment (LACReSNE), Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia; Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy University of Granada, Campus of Cartuja, 18071 s/n, Granada, Spain. Electronic address: cheikhdorsaf@gmail.com.
² Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy University of Granada, Campus of Cartuja, 18071 s/n, Granada, Spain.
³ Laboratory of Interfaces and Advanced Materials (LIMA), Faculty of Sciences of Monastir, University of Monastir, Bd. Of the environment, 5019, Monastir, Tunisia.
⁴ Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy University of Granada, Campus of Cartuja, 18071 s/n, Granada, Spain; Andalusian Institute of Earth Sciences, CS-CSIC-University of Granada, Avda. de Las Palmeras 4, 18100 Armilla, Granada, Spain.
⁵ Laboratory of Application of Chemistry to Natural Resources, Substances and the Environment (LACReSNE), Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia; High Institute of Environmental Sciences and Technologies (ISSTE), University of Carthage, Technopole of Borj Cedria B.P, Borj Cedria, 2050, Ben arous, Tunisia.

PMID: 30586582
DOI: 10.1016/j.ijbiomac.2018.12.205

Abstract

Chitosan (CS) and purified sodium beidellite (Na-Bd) were used to obtain a nanocomposite able to carry anionic pharmaceutical ingredients. Diclofenac sodium (DS) was chosen as a model drug and was loaded by intercalation solution technique. Solid state characterization of the resultant hybrids was performed, including X-ray diffraction, Fourier transformed infrared spectroscopy, Thermal analysis and high resolution transmission electron microscopy coupled with energy dispersive X-Ray analysis. Drug loading capacity and encapsulation efficiency were quantified by measuring equilibrium concentration by UV-Vis spectroscopy at 276 nm. Solid-state characterization of the samples confirmed both chemical and physical interaction of DS with the nanocomposites. High drug loading along with a modified cumulative release of the drug in simulated intestinal fluid was obtained. The developed clay/polymer hybrids can act as potential candidates for the design of modified dosage forms of anionic drugs.

Keywords: Beidellite; Chitosan; Clay/polymer nanocomposite; Diclofenac; Drug delivery.

MeSH terms

Aluminum Silicates / chemistry*
Calorimetry, Differential Scanning
Chitosan / chemistry*
Clay / chemistry
Diclofenac / chemistry
Diclofenac / pharmacology*
Drug Carriers / chemistry*
Drug Compounding
Drug Delivery Systems
Drug Liberation
Nanocomposites / chemistry*
Nanocomposites / ultrastructure
Spectrometry, X-Ray Emission
Spectroscopy, Fourier Transform Infrared
Thermogravimetry
X-Ray Diffraction

Substances

Aluminum Silicates
Drug Carriers
beidellite
Diclofenac
Chitosan
Clay