Abstract
Three new megastigmane glucosides (1-3) and two new monoterpenes (4-5), together with 14 related known compounds (6-19) were isolated from the twigs and leaves of Lyonia ovalifolia. The structures of the new compounds were determined by extensive MS, NMR, CD experiments and chemical methods. Compounds 2, 6, and 18 displayed potent antiviral activity against Coxsackie B3, with IC50 values between 6.4 and 14.6 µM. Additionally, compounds 6, 10, and 11 exhibited noteworthy anti-inflammatory activities, with inhibition rates ranging from 54.55% to 83.33% under the concentration of 10-5 M.
Keywords:
Ericaceae; anti-inflammatory activity; antiviral activity; megastigmane glucosides; monoterpenes.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Chlorocebus aethiops
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Cyclohexanones / chemistry*
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Cyclohexanones / pharmacology*
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Enterovirus / drug effects
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Ericaceae / chemistry*
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Glucosides / chemistry*
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Glucosides / pharmacology*
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Lipopolysaccharides / pharmacology
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Mice
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Molecular Structure
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Monoterpenes / chemistry
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Monoterpenes / pharmacology
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Nitric Oxide / antagonists & inhibitors
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Norisoprenoids / chemistry*
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Norisoprenoids / pharmacology*
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Plant Leaves
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RAW 264.7 Cells
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Vero Cells
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents, Phytogenic
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Antiviral Agents
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Cyclohexanones
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Glucosides
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Lipopolysaccharides
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Monoterpenes
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Norisoprenoids
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megastigmane
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Nitric Oxide