Active Kras Expression in Gastric Isthmal Progenitor Cells Induces Foveolar Hyperplasia but Not Metaplasia

Eunyoung Choi; Anna L Means; Robert J Coffey; James R Goldenring

doi:10.1016/j.jcmgh.2018.09.007

Active Kras Expression in Gastric Isthmal Progenitor Cells Induces Foveolar Hyperplasia but Not Metaplasia

Cell Mol Gastroenterol Hepatol. 2019;7(1):251-253.e1. doi: 10.1016/j.jcmgh.2018.09.007. Epub 2018 Sep 18.

Authors

Eunyoung Choi¹, Anna L Means², Robert J Coffey³, James R Goldenring⁴

Affiliations

¹ Nashville VA Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Section of Surgical Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee. Electronic address: eunyoung.choi@vumc.org.
² Section of Surgical Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
³ Nashville VA Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
⁴ Nashville VA Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Section of Surgical Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee. Electronic address: jim.goldenring@vanderbilt.edu.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Biomarkers / metabolism
Humans
Hyperplasia
Metaplasia
Mice
Proto-Oncogene Proteins p21(ras) / metabolism*
Stem Cells / metabolism*
Stomach / pathology*

Substances

Biomarkers
Hras protein, mouse
Proto-Oncogene Proteins p21(ras)

Publication types

MeSH terms

Substances

Grants and funding