A traditional lecture given during the annual meeting of the French Society of Dermatology in Paris summarizes the highlights of the scientific literature over the past year. In the current article the selection of the 2017-2018 period retains the following areas of interest: role of microbiome in the response to anti-PD-1 and in autoimmunity, PI3Kδ inhibitors in autoimmune bullous diseases, diagnostic and therapeutic applications of CRISPR/Cas, arrival of CAR-T cells therapy into clinical practice, gene therapy successes, use of targeted therapies in genodermatoses and integration of genetics in primary care. © 2018 Elsevier Masson SAS. All rights reserved.
Keywords: Autoimmune bullous diseases; CAR-T cells; CRISPR/Cas; Cellules CAR-T; Gene therapy; Maladies bulleuses auto-immunes; Microbiome; Targeted therapy; Thérapie génique; Thérapies ciblées.
© 2018 Elsevier Masson SAS. Tous droits réservés.