Nucleic acid aptamer is an oligonucleotide sequence screened by the exponential enrichment ligand system evolution technology (SELEX). Previous studies have shown that nucleic acid aptamer has a good application prospect in tumor diagnosis and treatment. Therefore, we reviewed the selection and identification of nucleic acid aptamer of lung cancer cells in recent years, and discussed the effect of aptamer as targeting drugs and targeting vectors on the diagnosis of tumors, which provide a new idea for early diagnosis and treatment of tumor.
核酸适配体是经过指数富集配体系统进化技术（SELEX）筛选得到的寡核苷酸序列。已有研究表明，核酸适配体在肿瘤诊断及治疗方面具有良好的应用前景。因此，本文主要针对肺癌细胞核酸适配体的筛选、表征等方面展开论述，初步探讨核酸适配体作为靶向载体和靶向药物在肿瘤诊断治疗中的作用，为肿瘤的早期诊断及早期治疗提供新思路。.
Keywords: aptamer; lung cancer cells; systematic evolution of ligands for cell exponential enrichment technology; tumor diagnosis and treatment.