Chemical characterization of constituents from Polygonatum cyrtonema Hua and their cytotoxic and antioxidant evaluation

Abstract

Twenty-four compounds were isolated from the roots of Polygonatum cyrtonema Hua, including a new octopamine dimer, named trans-bis(N-feruloyl)octopamine (1). The structure was established on the basis of spectroscopic and chemical methods. All the extracts and compounds were evaluated for cytotoxic and antioxidant activities by using MTT and chemiluminescence assay. The extracts showed activity against MCF-7 and HepG-2 cell lines from IC₅₀ 0.30 to 1.01 mg mL^-1. Compound 3 exhibited activity against HepG-2 cell lines with IC₅₀ 8.99 μM. Compound 7 exhibited activity against Hela cell lines with IC₅₀ 2.53 μM and BGC-823 cell lines with IC₅₀ 7.77 μM. Moreover, compound 7 showed antioxidant with IC₅₀ 12 µM compared to the positive control with IC₅₀ 77 µM. Compound 16 exhibited activity against HepG-2 cell lines with IC₅₀ 1.05 μM and MCF-7 cell lines with IC₅₀ 1.89 μM. These results indicated that this plant might be potential in natural medicine and healthy food.

Keywords: Polygonatum cyrtonema Hua; antioxidant; chemical constituents; cytotoxic.