A 61-year-old woman with a history of palpebral conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma, treated with rituximab, was referred to the authors' hospital after follow-up positron emission tomography/computed tomography revealed 18F-fluoro-2-deoxy-d-glucose uptake in a tumor located in the left main bronchus. The diagnosis of MALT lymphoma was made by pathological and immunohistochemical findings homologous to previous palpebral conjunctival lesion via bronchoscopic biopsy. The disease was controlled with rituximab, cyclophosphamide, oncovin, and prednisolone (i.e., R-COP) chemotherapy. Although MALT lymphoma occurs in several organs, metachronous occurrence in the palpebral conjunctiva and bronchus is especially rare, and careful check-up is required to monitor for occurrence of systemic relapse.
Keywords: Bronchus; CEA, Carcinoembryonic antigen; FDG, 18F-fluoro-2-deoxy-d-glucose; MALT, Mucosa-associated lymphoid tissue; Mucosa-associated lymphoid tissue (MALT) lymphoma; PET/CT, positron emission tomography/computed tomography; Palpebral conjunctiva; ProGRP, Pro gastrin releasing peptide; SCC, Squamous cell carcinoma antigen.