TNFα-Driven Astrocyte Purinergic Signaling during Epileptogenesis

Peter Bedner; Christian Steinhäuser

doi:10.1016/j.molmed.2018.12.001

TNFα-Driven Astrocyte Purinergic Signaling during Epileptogenesis

Trends Mol Med. 2019 Feb;25(2):70-72. doi: 10.1016/j.molmed.2018.12.001. Epub 2018 Dec 20.

Authors

Peter Bedner¹, Christian Steinhäuser²

Affiliations

¹ Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
² Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. Electronic address: cste@uni-bonn.de.

PMID: 30581052
DOI: 10.1016/j.molmed.2018.12.001

Abstract

The etiology of temporal lobe epilepsy is unclear, but proinflammatory molecules and disturbed neuron-glia communications are emerging as potential causers. A recent study (Nikolic et al. Glia 2018; https://doi.org/10.1002/glia.23519) revealed that pathologically elevated tumor necrosis factor α contributes to epileptogenesis, by boosting hyperexcitation through an autocrine mechanism involving purinergic signaling, astrocyte glutamate release, and modulation of neuronal transmitter release.

Keywords: P2Y1 receptor; TNFα; astrocyte; epilepsy; gliotransmission.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Astrocytes*
Epilepsy, Temporal Lobe*
Glutamic Acid
Humans
Signal Transduction
Tumor Necrosis Factor-alpha

Substances

Tumor Necrosis Factor-alpha
Glutamic Acid