Patients With Chronic Liver Disease Suggestive of Nonalcoholic Fatty Liver Disease May Be at Higher Risk for Drug-Induced Liver Injury

Craig Lammert; Timothy Imler; Evgenia Teal; Naga Chalasani

doi:10.1016/j.cgh.2018.12.013

Patients With Chronic Liver Disease Suggestive of Nonalcoholic Fatty Liver Disease May Be at Higher Risk for Drug-Induced Liver Injury

Clin Gastroenterol Hepatol. 2019 Dec;17(13):2814-2815. doi: 10.1016/j.cgh.2018.12.013. Epub 2018 Dec 20.

Authors

Craig Lammert¹, Timothy Imler², Evgenia Teal³, Naga Chalasani⁴

Affiliations

¹ Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
² Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; The Regenstrief Institute, Indianapolis, Indiana.
³ The Regenstrief Institute, Indianapolis, Indiana.
⁴ Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: nchalasa@iu.edu.

PMID: 30580093
DOI: 10.1016/j.cgh.2018.12.013

Abstract

To date, there have been no studies that systematically examined if individuals with nonalcoholic fatty liver disease (NAFLD) have an increased risk of drug-induced liver injury (DILI). We conducted a study to test if the frequency of suspected DILI from prescription agents is higher in individuals with chronic liver disease (CLD) suggestive of NAFLD.

MeSH terms

Alanine Transaminase / blood
Alkaline Phosphatase / blood
Bilirubin / blood
Case-Control Studies
Cefazolin
Chemical and Drug Induced Liver Injury / etiology*
Cohort Studies
Female
Humans
Liver Transplantation / statistics & numerical data
Male
Middle Aged
Non-alcoholic Fatty Liver Disease / blood
Non-alcoholic Fatty Liver Disease / drug therapy*
Risk Assessment

Substances

Alanine Transaminase
Alkaline Phosphatase
Cefazolin
Bilirubin