Heme oxygenase-1 as a potential therapeutic target in rheumatic diseases

Abstract

Background: Heme oxygenase-1 (HO-1), a cellular stress protein, serves a vital metabolic function as the rate-limiting enzyme in the degradation of heme to generate carbon monoxide (CO), iron, and biliverdin (BR). HO-1 may function as one of the most momentous factors of cell adaptation to oxidase stress, as well as a regulator of inflammatory signaling programs through the generation of its biologically active end products. Intensive investigation is now focusing on the potential function of HO-1 in inflammatory disorders, among which rheumatic diseases are one of the principal issues.

Methods: "Heme oxygenase-1", "rheumatic diseases"; "lupus", "rheumatic arthritis", "osteoarthritis" and "oxidative stress" were used as key words for searching in Pubmed and Google scholar database.

Results: Collected information from the related articles revealed the important role of pathogenesis and therapeutic potential of HO-1 in rheumatic diseases. Conclusions and discussions HO-1 has potential as a target for the treatment of rheumatic diseases due to its characteristic anti-inflammatory and anti-oxidative role. However, it is essential to monitor the HO-1 expression during particular stage of the disorders, and levels of HO-1 in different tissues and organs should be further confirmed in order to correlate it with clinical symptoms and other hallmarks of rheumatic diseases.

Keywords: Heme oxygenase-1 (HO-1); Lupus; Osteoarthritis; Oxidative stress; Rheumatic arthritis; Rheumatic diseases.