The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System

Cells. 2018 Dec 20;8(1):2. doi: 10.3390/cells8010002.

Abstract

Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maintenance of cell homeostasis. The two pathways differ in their mechanisms and clients. The evolutionary conserved ATG16 plays a key role in autophagy and appears to link autophagy with the UPS. Here, we review the role of ATG16 in different species. We summarize the current knowledge of its functions in autophagosome membrane expansion and autophagosome formation, in Crohn's disease, and in bacterial sequestration. In addition, we provide information on its autophagy-independent functions and its role in the crosstalk between autophagy and the UPS.

Keywords: ATG16; UPS; autophagy; crosstalk; ubiquitin proteasome system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy*
  • Autophagy-Related Proteins / physiology*
  • Bacterial Infections / metabolism
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins / physiology*
  • Carrier Proteins / physiology*
  • Crohn Disease / metabolism
  • Dictyostelium / metabolism
  • Drosophila Proteins / physiology*
  • Drosophila melanogaster / metabolism
  • Humans
  • Mice
  • Proteasome Endopeptidase Complex / metabolism*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / physiology*
  • Ubiquitin / metabolism

Substances

  • ATG16 protein, S cerevisiae
  • ATG16L1 protein, human
  • Atg16 protein, Drosophila
  • Autophagy-Related Proteins
  • Caenorhabditis elegans Proteins
  • Carrier Proteins
  • Drosophila Proteins
  • Saccharomyces cerevisiae Proteins
  • Ubiquitin
  • atg-16.1 protein, C elegans
  • Proteasome Endopeptidase Complex