3D point cloud registration is a key technology in 3D point cloud processing, such as 3D reconstruction, object detection. Trimmed Iterative Closest Point algorithm is a prevalent method for registration of two partially overlapping clouds. However, it relies heavily on the initial value and is liable to be trapped in to local optimum. In this paper, we adapt the Differential Evolution algorithm to obtain global optimal solution. By design appropriate evolutionary operations, the algorithm can make the populations distributed more widely, and keep the individuals from concentrating to a local optimum. In the experiment, the proposed algorithm is compared with existing methods which are based on global optimization algorithm such as Genetic Algorithm and particle filters. And the results have demonstrated that the proposed algorithm is more robust and can converge to a good result in fewer generations.