Pyrrolopyrrole aza-BODIPY near-infrared photosensitizer for dual-mode imaging-guided photothermal cancer therapy

Chem Commun (Camb). 2019 Jan 15;55(6):790-793. doi: 10.1039/c8cc07768a.

Abstract

A NIR photosensitizer pyrrolopyrrole aza-BODIPY (PPAB) was synthesized in a straightforward manner. Through the use of PPAB NPs as a photothermal agent, photoacoustic imaging (PAI) and NIR fluorescence imaging (NIR-FI) can be achieved in vivo. In addition, the photothermal ablation of tumor cells can be realized both in vitro and in vivo, even at a low concentration (0.5 mg kg-1).

MeSH terms

  • Animals
  • Boron Compounds / chemistry*
  • HeLa Cells
  • Humans
  • Infrared Rays
  • Mice
  • Microscopy, Confocal
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Optical Imaging
  • Photoacoustic Techniques
  • Photosensitizing Agents / chemical synthesis
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / therapeutic use
  • Phototherapy
  • Pyrroles / chemistry*
  • Transplantation, Heterologous

Substances

  • Boron Compounds
  • Photosensitizing Agents
  • Pyrroles
  • azaBDPBA compound