State-of-the-art radionuclide imaging in cardiac transthyretin amyloidosis

Vasvi Singh; Rodney Falk; Marcelo F Di Carli; Marie Kijewski; Claudio Rapezzi; Sharmila Dorbala

doi:10.1007/s12350-018-01552-4

State-of-the-art radionuclide imaging in cardiac transthyretin amyloidosis

J Nucl Cardiol. 2019 Feb;26(1):158-173. doi: 10.1007/s12350-018-01552-4. Epub 2018 Dec 19.

Authors

Vasvi Singh¹, Rodney Falk², Marcelo F Di Carli¹, Marie Kijewski¹, Claudio Rapezzi³, Sharmila Dorbala^{4

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Affiliations

¹ Division of Nuclear Medicine and Department of Radiology, Brigham and Women's Hospital, Boston, MA, 2115, USA.
² Cardiac Amyloidosis Program, Brigham and Women's Hospital, Boston, MA, 2115, USA.
³ Cardiology, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
⁴ Division of Nuclear Medicine and Department of Radiology, Brigham and Women's Hospital, Boston, MA, 2115, USA. sdorbala@bwh.harvard.edu.
⁵ Cardiac Amyloidosis Program, Brigham and Women's Hospital, Boston, MA, 2115, USA. sdorbala@bwh.harvard.edu.
⁶ Cardiac Amyloidosis Program, Cardiovascular Division, Department of Medicine, Heart and Vascular Center, Division of Nuclear Medicine and Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA. sdorbala@bwh.harvard.edu.

Abstract

Cardiac amyloidosis, once considered untreatable, is now gaining well-deserved attention due to advances in imaging and the recent approval of targeted breakthrough therapies. In this paper, we discuss the role of radionuclide imaging in the evaluation and management of patients with the most common form of amyloidosis-cardiac transthyretin amyloidosis (ATTR). We provide a comprehensive summary of the literature interspersed with our institutional experience as appropriate, to deliver our perspective.

Keywords: Amyloid heart disease; PET; SPECT; modalities; molecular imaging.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Amyloid Neuropathies, Familial / diagnostic imaging
Amyloidosis / diagnostic imaging*
Bone and Bones / diagnostic imaging
Cardiomyopathies / diagnostic imaging
Heart / diagnostic imaging*
Humans
Prealbumin / metabolism*
Radionuclide Imaging
Technetium Tc 99m Medronate
Technetium Tc 99m Pyrophosphate
Tomography, Emission-Computed, Single-Photon

Substances

Prealbumin
Technetium Tc 99m Pyrophosphate
Technetium Tc 99m Medronate

Supplementary concepts

Amyloidosis, Hereditary, Transthyretin-Related

Grants and funding

R01 HL130563/HL/NHLBI NIH HHS/United States