Duration of Colonization by Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Healthy Newborns and Associated Risk Factors: A Prospective Cohort Study

María Jesús Rodríguez-Revuelta; Lorena López-Cerero; Lara Serrano; Salud Luna-Lagares; Alvaro Pascual; Jesús Rodríguez-Baño

doi:10.1093/ofid/ofy312

Duration of Colonization by Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Healthy Newborns and Associated Risk Factors: A Prospective Cohort Study

Open Forum Infect Dis. 2018 Nov 20;5(12):ofy312. doi: 10.1093/ofid/ofy312. eCollection 2018 Dec.

Authors

María Jesús Rodríguez-Revuelta¹, Lorena López-Cerero², Lara Serrano², Salud Luna-Lagares¹, Alvaro Pascual², Jesús Rodríguez-Baño²

Affiliations

¹ Unidad de Neonatología, Unidad de Gestión Clínica de Pediatría, Hospital Universitario Virgen Macarena, Seville, Spain.
² Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena/Instituto de Biomedicina de Sevilla (IBiS)/CSIC/Departamentos de Microbiología y Enfermedades Infecciosas, Universidad de Sevilla, Spain.

Abstract

Duration of colonization by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) and factors associated with it were studied in 20 newborns in Seville, Spain. Median duration of colonization was 7.5 months; factors associated with prolonged colonization were delivery by caesarean section, colonization of the mother, and phylogroup B2 Eschericha coli isolate.

Keywords: Escherichia coli; colonization; extended-spectrum β-lactamases; newborns; risk factors.