One-way waveguides have been discovered as topological edge states in two-dimensional (2D) photonic crystals. Here, we design one-way fiber modes in a 3D magnetic Weyl photonic crystal realizable at microwave frequencies. We first obtain a 3D Chern crystal with a non-zero first Chern number by annihilating the Weyl points through supercell modulation. When the modulation becomes helixes, one-way modes develop along the winding axis, with the number of modes determined by the spatial frequency of the helix. These single-polarization single-mode and multi-mode one-way fibers, having nearly identical group and phase velocities, are topologically-protected by the second Chern number in the 4D parameter space of the 3D wavevectors plus the winding angle of the helix. This work suggests a unique way to utilize high-dimensional topological physics using topological defects.