Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment

Blood Adv. 2018 Dec 26;2(24):3602-3607. doi: 10.1182/bloodadvances.2018022020.

Abstract

  1. Fetal injection of antibodies against the c-Kit receptor and CD47 effectively depletes host HSCs in immunocompetent mice.

  2. In utero depletion of host HSCs increases long-term engraftment after neonatal hematopoietic cell transplantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / immunology
  • CD47 Antigen / immunology
  • CD47 Antigen / metabolism*
  • Female
  • Fetal Stem Cells / cytology*
  • Fetal Stem Cells / immunology
  • Fetal Therapies
  • Graft Survival / physiology*
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Pregnancy
  • Proto-Oncogene Proteins c-kit / immunology
  • Proto-Oncogene Proteins c-kit / metabolism*
  • Receptors, Immunologic / metabolism
  • Transplantation Conditioning

Substances

  • Antibodies, Monoclonal
  • CD47 Antigen
  • Ptpns1 protein, mouse
  • Receptors, Immunologic
  • Proto-Oncogene Proteins c-kit