Abstract
Fetal injection of antibodies against the c-Kit receptor and CD47 effectively depletes host HSCs in immunocompetent mice.
In utero depletion of host HSCs increases long-term engraftment after neonatal hematopoietic cell transplantation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / immunology
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CD47 Antigen / immunology
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CD47 Antigen / metabolism*
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Female
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Fetal Stem Cells / cytology*
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Fetal Stem Cells / immunology
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Fetal Therapies
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Graft Survival / physiology*
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Hematopoietic Stem Cell Transplantation
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / metabolism*
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Mice
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Mice, Inbred C57BL
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Pregnancy
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Proto-Oncogene Proteins c-kit / immunology
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Proto-Oncogene Proteins c-kit / metabolism*
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Receptors, Immunologic / metabolism
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Transplantation Conditioning
Substances
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Antibodies, Monoclonal
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CD47 Antigen
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Ptpns1 protein, mouse
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Receptors, Immunologic
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Proto-Oncogene Proteins c-kit