Unusual case of Lemierre's syndrome

BMJ Case Rep. 2018 Nov 28;11(1):e226948. doi: 10.1136/bcr-2018-226948.

Abstract

A young previously healthy patient presented with sepsis and cavitating pneumonia. Campylobacter rectus was isolated from blood cultures and subsequent CT neck showed an internal jugular vein thrombosis. Treatment was with antibiotics, anticoagulation and supportive management. Lemierre's syndrome is an infectious thrombophlebitis of the internal jugular vein. Although a rare diagnosis since the use of penicillin for treatment of acute pharyngitis, it is being reported with increasing frequency. Usually associated with Fusobacterium spp, we believe that this is the first reported case of Lemierre's caused by C. rectus-an anaerobic member of the human oral cavity flora, usually associated with localised periodontal disease. The bacillus was isolated from blood during the acute presentation.

Keywords: infectious diseases; pneumonia (infectious disease).

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Anticoagulants / therapeutic use
  • Campylobacter rectus / isolation & purification
  • Computed Tomography Angiography / methods
  • Diagnosis, Differential
  • Humans
  • Jugular Veins / diagnostic imaging
  • Jugular Veins / pathology
  • Lemierre Syndrome / complications
  • Lemierre Syndrome / diagnosis*
  • Lemierre Syndrome / drug therapy
  • Lemierre Syndrome / pathology
  • Male
  • Penicillins / therapeutic use
  • Pharyngitis / drug therapy
  • Pneumonia / blood
  • Pneumonia / diagnostic imaging
  • Pneumonia / drug therapy
  • Pneumonia / microbiology*
  • Sepsis
  • Thrombophlebitis / drug therapy*
  • Thrombophlebitis / pathology
  • Thrombophlebitis / prevention & control
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome
  • Venous Thrombosis / pathology

Substances

  • Anti-Bacterial Agents
  • Anticoagulants
  • Penicillins