Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart

Lauren E Neidig; Florian Weinberger; Nathan J Palpant; John Mignone; Amy M Martinson; Daniel W Sorensen; Ingrid Bender; Natsumi Nemoto; Hans Reinecke; Lil Pabon; Jeffery D Molkentin; Charles E Murry; Jop H van Berlo

doi:10.1161/CIRCULATIONAHA.118.035273

Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart

Circulation. 2018 Dec 18;138(25):2960-2962. doi: 10.1161/CIRCULATIONAHA.118.035273.

Authors

Lauren E Neidig^{1

2

3

4}, Florian Weinberger^{1

2

3

5}, Nathan J Palpant^{1

2

3

6}, John Mignone^{2

3

7

8}, Amy M Martinson^{1

2

3}, Daniel W Sorensen⁹, Ingrid Bender⁹, Natsumi Nemoto⁹, Hans Reinecke^{1

2

3}, Lil Pabon^{1

2

3}, Jeffery D Molkentin¹⁰, Charles E Murry^{1

2

3

7

11}, Jop H van Berlo⁹

Affiliations

¹ Department of Pathology (L.E.N., F.W., N.J.P., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
² Institute for Stem Cell and Regenerative Medicine (L.E.N., F.W., N.J.P., J.M., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
³ Center for Cardiovascular Biology (L.E.N., F.W., N.J.P., J.M., A.M.M., H.R., L.P., C.E.M.), University of Washington, Seattle.
⁴ Department of Comparative Medicine (L.E.N), University of Washington, Seattle.
⁵ F.W. is currently at the Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Germany.
⁶ N.J.P. is currently at the Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
⁷ Department of Medicine/Cardiology (J.M., C.E.M.), University of Washington, Seattle.
⁸ J.M. is currently at the Cardiology Division, Swedish Medical Center, Seattle, WA.
⁹ Stem Cell Institute and Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis (D.W.S., I.B., N.N., J.H.v.B.).
¹⁰ Department of Pediatrics, Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.D.M.).
¹¹ Department of Bioengineering (C.E.M.), University of Washington, Seattle.

No abstract available

Keywords: heart failure; myocardial infarction; progenitor cells; regeneration.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult Stem Cells / physiology*
Animals
Antigens, Ly / genetics
Antigens, Ly / metabolism*
Cell Differentiation
Cell Lineage
Cell Self Renewal
Cells, Cultured
Endothelial Cells / physiology*
Humans
Membrane Proteins / genetics
Membrane Proteins / metabolism*
Mice
Mice, Transgenic
Models, Animal
Muscle Development
Myocardial Infarction / physiopathology*
Myocytes, Cardiac / physiology*
Regeneration
Tamoxifen

Substances

Antigens, Ly
Ly6a protein, mouse
Membrane Proteins
Tamoxifen

Publication types

MeSH terms

Substances

Grants and funding